Aiming at the desigh problem of the homing missile man-in-the-loop fight control system, the method of combining Vega/Creator virtual simulation with the flight control system design is brought forward. According to the operator’s operation, the data from the stick device are real-time dealt with, the closed homing system including kinetics of human body is adopted, so the man-in-the-loop system design is formed. Simulational result shows that the adaptive capacity of flight control system can be inspected and the parameters of control system can be designed by means necessary experiments, the man-in-the-loop design problem is solved.